Edit |   |
---|---|
Antigenic Specificity | IFT57 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway. Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear. |
Immunogen | Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 170-429 of human IFT57 (NP 060480.1). |
Other Names | [HIPPI; OFD18; MHS4R2; ESRRBL1] |
Gene, Accession # | [IFT57], Gene ID: 55081, NCBI: NP_060480.1, UniProt: Q9NWB7 |
Catalog # | MBS8546642 |
Price | $280 |
Order / More Info | IFT57 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |