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Antigenic Specificity | GSK-3alpha |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | affinity purified |
Size | 0.03 mg, 0.1 mg |
Concentration | 0.5 mg/ml |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Polyclonal Antibody to detect GSK-3alpha in human samples. Background: Glycogen synthase kinase 3-alpha is a multifunctional protein serine kinase. GSK-3 phosphorylates and inactivates glycogen synthase. It has also been implicated in the regulation of cell fate in Dictyostelium and is a component of the Wnt signaling pathway required for Drosophila, Xenopus, and mammalian development. GSK-3 has been shown to regulate Cyclin D1 proteolysis and subcellular localization. GSK-3alpha (GSK-3alpha) regulates the production of amyloid-beta peptides, a major component of the plaques that accumulate with progression of Alzheimer's disease, by phosphorylating Tau proteins. This presents the possibility that defects in GSK-3 signaling can contribute t |
Immunogen | Immunogen: Human recombinant GSK-3alpha. Positive Control: Western Blot: 3T3 cell lysate |
Other Names | [Serine/threonine-protein kinase GSK3A; GSK-3alpha; Glycogen synthase kinase-3; GSK-3 alpha], [GSK3A; GSK3A; GSK-3 alpha] |
Gene, Accession # | Gene ID: 2931, NCBI: NP_063937.2, UniProt: P49840 |
Catalog # | MBS840780 |
Price | $150, $305 |
Order / More Info | GSK-3alpha Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |