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Antigenic Specificity | Catenin-b (pS675) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | epitope affinity purified |
Size | 0.1 mg |
Concentration | n/a |
Applications | ELISA (EIA), Flow Cytometry (FC/FACS), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Beta-catenin, a cytosolic, 88 kDa, 781 amino acid protein, belongs to the beta-catenin family. The N-terminus domain, contains the binding site and the phosphorylation sites. Beta-Catenin serves as a link between cytoskeleton actin and transmembrane cadherin (s). It is believed to contribute to tight cell-to-cell adhesion. It can enter the nucleus and interact with the TCF/LEF family of transcription factors, initiating gene expression. Normally, beta-catenin transcriptional activity is suppressed by a Ser/Thr kinase termed GSK3beta and/or Casein Kinase I (CK1). Kinases are constitutively active and phosphorylates beta-catenin at multiple sites, including S33 and S37, Y96, Y228, Y280, S675, etc. Phosphorylation of beta-catenin targets the m |
Immunogen | n/a |
Other Names | n/a |
Gene, Accession # | Gene ID: 1499 |
Catalog # | MBS460295 |
Price | $285 |
Order / More Info | Catenin-b (pS675) Antibody from MYBIOSOURCE INC. |
Product Specific References | Park, C.S. et al. (2004) J. Biol. Chem. 279:19592. |