HER-4/ERBB4 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | HER-4/ERBB4 |
| Clone | [ERBB4/2582] |
| Host Species | Mouse |
| Reactive Species | human. |
| Isotype | IgG2b, kappa |
| Format | purified |
| Size | n/a |
| Concentration | n/a |
| Applications | Immunohistology (Formalin-Fixed) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | The EGF receptor family comprises several related receptor tyrosine kinases that are frequently overexpressed in a variety of carcinomas. Members of this receptor family include EGFR (HER1), Neu (ErbB-2, HER2), ErbB-3 (HER3) and ErbB-4 (HER4), which form either homodimers or heterodimers upon ligand binding. The gene encoding ErbB-4 is expressed as a full-length protein, which produces a short membrane-anchored cytoplasmic domain fragment and a long ectodomain fragment. The short fragment is heavily tyrosine phosphorylated and possesses tyrosine kinase catalytic activity toward an exogenous substrate. Proteolytic cleavage of ErbB-4 is promoted by the binding of heregulin. ErbB-4 is involved in cell proliferation and differentiation and its |
| Immunogen | Immunogen: Recombinant human ERBB4 (HER4) protein fragment (around aa 1116-1269) (exact sequence is proprietary) Positive Control: Breast, Brain, Heart or Kidney |
| Other Names | [Avian erythroblastic leukemia viral oncogene homolog 4; ERBB4; HER4; human epidermal growth factor receptor 4; p180erbB4; Proto-oncogene-like protein c-ErbB-4] |
| Gene, Accession # | [ERBB4], Gene ID: 2066, NCBI: NP_001036064.1, UniProt: Q15303 |
| Catalog # | MBS4380550 |
| Price | please inquire |
| Order / More Info | HER-4/ERBB4 Antibody from MYBIOSOURCE INC. |
| Product Specific References | Carpenter, G. (2003) Exp Cell Res 284, 66-77. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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