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Antigenic Specificity | EWSR1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, rat, mouse, dog |
Isotype | n/a |
Format | epitope affinity purified |
Size | 0.1 mg |
Concentration | Size: 100 ug/200 ul |
Applications | ELISA, Western Blot, Immunohistochemistry |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This antibody recognizes ~70 kDa of EWSR1 protein. It also cross reacts with human, mouse and rat tissues. The other species are not tested. The EWSR1 gene encodes a putative RNA binding protein. Mutation in this gene causes Ewing sarcoma and neuroectodermal and various other tumors. This gene is involved in a number of different sarcomas as a result of chromosomal translocations. EWSR1 is fused to an ETS transcription factor (FLI-1, ERG, ETV-1, E1AF or FEV) in Ewing sarcoma; to activating transcription factor-1 (ATF-1) in soft tissue clear cell sarcoma; to Wilms Tumor -1 (WT1) in desmoplastic small round cell; to nuclear receptor 4A3 (NR4A3) in extraskeletal myxoid chondrosarcoma, and to C/EBPhomologous protein (CHOP) in myxoid liposarcoma |
Immunogen | Antigen Preparation: A synthetic peptide corresponding to the internal segment of EWSR1 protein. This sequence is identical among human, rat, mouse and dog species. |
Other Names | n/a |
Gene, Accession # | [EWSR] |
Catalog # | MBS462243 |
Price | $270 |
Order / More Info | EWSR1 Antibody from MYBIOSOURCE INC. |
Product Specific References | Melot,T., et al. Characterization of a new brain-specific isoform of the EWS oncoprotein. Eur. J. Biochem. 268 (12), 3483-3489 (2001) |