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Antigenic Specificity | FGR (N-term), 3-33 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | purified |
Size | 0.08 mL, 0.4 mL |
Concentration | vial concentration: 2 |
Applications | Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This FGR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 3-33 amino acids from the N-terminal region of human FGR. FGR is a member of the Src family of protein tyrosine kinases (PTKs). This protein contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. It localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this protein. |
Immunogen | n/a |
Other Names | [Tyrosine-protein kinase Fgr; Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog; Proto-oncogene c-Fgr; p55-Fgr; p58-Fgr; p58c-Fgr; FGR; SRC2] |
Gene, Accession # | [FGR], Gene ID: 2268, NCBI: NP_001036194.1, UniProt: P09769 |
Catalog # | MBS9205001 |
Price | $165, $370 |
Order / More Info | FGR (N-term), 3-33 Antibody from MYBIOSOURCE INC. |
Product Specific References | Carriero, M.V., et al., Biol. Chem. 383(1):107-113 (2002). Katamine, S., et al., Mol. Cell. Biol. 8(1):259-266 (1988). Nishizawa, M., et al., Mol. Cell. Biol. 6(2):511-517 (1986). Cheah, M.S., et al., Nature 319(6050):238-240 (1986). Tronick, S.R., et al., Proc. Natl. Acad. Sci. U.S.A. 82(19):6595-6599 (1985). |