Edit |   |
---|---|
Antigenic Specificity | HIF-1 beta/ARNT |
Clone | monoclonal |
Host Species | Mouse |
Reactive Species | mouse |
Isotype | IgG1 |
Format | immunogen affinity purified |
Size | 0.1 mL |
Concentration | 1 mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC) Paraffin |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | ARNT (aryl hydrocarbon receptor nuclear translocator) encodes a protein containing a basic helix-loop-helix domain and two characteristic PAS domains along with a PAC domain. The encoded protein binds to ligand-bound aryl hydrocarbon receptor and aids in the movement of this complex to the nucleus, where it promotes the expression of genes involved in xenobiotic metabolism. This protein is also a co-factor for transcriptional regulation by hypoxia-inducible factor 1. Chromosomal translocation of ARNT with the ETV6 (ets variant 6) gene on chromosome 12 have been described in leukemias. Alternative splicing results in multiple transcript variants. |
Immunogen | Immunogen: Recombinant Protein |
Other Names | [Mouse HIF-1 beta/ARNT; ARNT; BHLHE2; Aryl hydrocarbon receptor nuclear translocator; ARNT protein; Class E basic helix-loop-helix protein 2; bHLHe2; Dioxin receptor, nuclear translocator; Hypoxia-inducible factor 1-beta; HIF-1-beta; HIF1-beta] |
Gene, Accession # | [HIF-1beta/ARNT], Gene ID: 405, NCBI: NP_001184254.1, UniProt: P27540 |
Catalog # | MBS9700329 |
Price | $250, $250 |
Order / More Info | HIF-1 beta/ARNT Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |