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Antigenic Specificity | Neuropilin 1, Non-Phosphospecific |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, bovine |
Isotype | n/a |
Format | epitope affinity purified |
Size | 0.1 mg |
Concentration | Size: 100 ug/200 ul |
Applications | ELISA, Western Blot, Immunohistochemistry |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This antibody recognizes ~130 kDa of human Neuropilin1 protein without phosphorylation site of Thr 916. It does not cross react to phospho Neuropilin 1. The other species are not tested. The neuropilin-1 (Nrp1) is a multifunctional protein, identified principally as a receptor for the class 3 semaphorins and members of the vascular endothelial growth factor (VEGF) family, but it is capable of other interactions. It is a marker of regulatory T cells (Tr), which often carry Nrp1 and latency-associated peptide (LAP)-TGF-beta1 (the latent form). Nrp1 is reported to be expressed in breast cancer cells. The ischemia can increase neuropilin 1 protein expression in experimental rat brain as well. The phosphorylation of Nrp1 is essential for the Nrp |
Immunogen | Antigen Preparation: A synthetic peptide surrounding the epitope -LNTQS- without phosphorylation site at Thr916. This sequence is identical among human and bovine. |
Other Names | [Rabbit Neuropilin1 (Paired Thr916); CD304 antigen; NRP1; VEGF Receptor], [NRP1; NRP1; NP1; NRP; BDCA4; CD304; VEGF165R; DKFZp781F1414; DKFZp686A03134; NRP; VEGF165R] |
Gene, Accession # | [Neuropilin-1 (Paired T916)], Gene ID: 8829, NCBI: NP_003864.4, UniProt: O14786 |
Catalog # | MBS462091 |
Price | $285 |
Order / More Info | Neuropilin 1, Non-Phosphospecific Antibody from MYBIOSOURCE INC. |
Product Specific References | Eldar Hochman et al. Molecular Pathways Regulating Pro-migratory Effects of Hedgehog Signaling. J. Biol. Chem., Vol. 281, Issue 45, 33860-33870, November 10, 2006 Glinka Y, et al. Neuropilin-1 is a receptor for transforming growth factor beta-1, activates its latent form, and promotes regulatory T cell activity. J Leukoc Biol. 2008 Jul; 84 (1): 302-10. Epub 2008 Apr 24 |