Human Lyve-1 Antibody from MYBIOSOURCE INC.

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Antigenic SpecificityHuman Lyve-1
Clonepolyclonal
Host SpeciesRabbit
Reactive Specieshuman
Isotypen/a
FormatProtein A purified
Size0.1 mg
Concentrationn/a
ApplicationsWestern Blot (WB), Immunohistochemistry (IHC) - Formalin/Paraffin, Immunofluorescence (IF)
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DescriptionLYVE-1 has been identified as a major receptor for HA (extracellular matrix glycosaminoglycan hyaluronan) on the lymph vessel wall. The deduced amino acid sequence of LYVE-1 predicts a 322-residue type I integral membrane polypeptide 41% similar to the CD44 HA receptor with a 212-residue extracellular domain containing a single Link module the prototypic HA binding domain of the Link protein superfamily. Like CD44, the LYVE-1 molecule binds both soluble and immobilized HA. However, unlike CD44, the LYVE-1 molecule colocalizes with HA on the luminal face of the lymph vessel wall and is completely absent from blood vessels. Hence, LYVE-1 is the first lymph-specific HA receptor to be characterized and is a uniquely powerful marker for lymph ve
ImmunogenAntibody Generation: Produced from sera of rabbits immunized with highly pure recombinant human soluble LYVE-1 produced in insect cells. The recombinant soluble LYVE-1consists of amino acid 24 (Ser) to 232 (Gly) and is fused to a C-terminal His-tag (6xHis). LYVE-1 has been identified as a major receptor for HA (extracellular matrix glycosaminoglycan hyaluronan) on the lymph vessel wall. The deduced amino acid sequence of LYVE-1 predicts a 322-residue type I integral membrane polypeptide 41% simi
Other Names[human LYVE-1; Lymphatic vessel endothelial hyaluronic acid receptor1], [LYVE1; LYVE1; HAR; XLKD1; LYVE-1; CRSBP-1; CRSBP1; HAR; XLKD1; LYVE-1; CRSBP-1]
Gene, Accession #[Lyve-1], Gene ID: 10894, NCBI: NP_006682.2, UniProt: Q9Y5Y7
Catalog #MBS691439
Price$280
Order / More InfoHuman Lyve-1 Antibody from MYBIOSOURCE INC.
Product Specific References1. Carriera et al., Cancer Res 61:8079, 2001 2. Jackson DG Trends Cardiovasc Med 13:1, 2003 3. Sleeman et al., Microsc Res Tech 55:61, 2001 4. Makinen et al., EMBO J 20 : 4762, 2001
MYBIOSOURCE INC.
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166

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