Shc1 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | Shc1 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | epitope affinity purified |
| Size | 0.1 mg |
| Concentration | 1ug/ul |
| Applications | Western Blot (WB), Immunohistochemistry (IHC) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: Shc1 (Phospho-Tyr427) antibody detects endogenous levels of Shc1 only when phosphorylated at tyrosine 427. This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by R |
| Immunogen | Immunogen: The antiserum was produced against synthesized phosphopeptide derived from human Shc1 around the phosphorylation site of tyrosine 427 (P-S-YP-V-N). |
| Other Names | [SHC1 protein; SHC-transforming protein 1; SHC-transforming protein 1; SH2 domain protein C1; SHC (Src homology 2 domain-containing) transforming protein 1; SHC-transforming protein 3; SHC-transforming protein A; SHC (Src homology 2 domain containing) transforming protein 1; SHC-transforming protein 3; SHC-transforming protein A; Src homology 2 domain-containing-transforming protein C1; SH2 domain protein C1], [SHC1; SHC1; SHC; SHCA] |
| Gene, Accession # | [Shc1], Gene ID: 6464, NCBI: AAH33925.1 |
| Catalog # | MBS417350 |
| Price | $325 |
| Order / More Info | Shc1 Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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