Edit |   |
---|---|
Antigenic Specificity | Smad3 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, rat |
Isotype | n/a |
Format | antigen affinity purified |
Size | 0.02 mL, 0.06 mL, 0.12 mL |
Concentration | 4mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and |
Immunogen | Immunogen: Recombinant human Mothers against decapentaplegic homolog 3 protein Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Other Names | [HSPC193; HST17436; LDS3; Mad protein homolog; MAD; MADH3; SMA and MAD related protein 3; SMAD family member 3; SMAD; mothers against DPP homolog 3; Smad3] |
Gene, Accession # | [Smad3], Gene ID: 4088 |
Catalog # | MBS2541745 |
Price | $110, $150, $225 |
Order / More Info | Smad3 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |