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Antigenic Specificity | IRE1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mg |
Concentration | 0.59-0.68 ug/ul in antibody stabilization buffer |
Applications | ELISA (EIA), IMM, Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Affinity Purified Serine/Threonine-protein kinase/endoribonuclease IRE1 Antibody. Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis. |
Immunogen | Immunogen: Synthetic peptide corresponding to unique amino acid sequence within amino acid region 900-1000 on human IRE1A protein. Immunoglobulin: IgG. Expression: Ubiquitously expressed. High levels observed in pancreatic tissue. |
Other Names | [Endoplasmic reticulum (ER) to nucleus signalling 1 Endoribonuclease ER to nucleus signaling 1; ERN 1; hIRE 1p Inositol requiring 1 Inositol requiring protein 1 IRE 1 IRE 1a IRE 1P Ire1 alpha; IRE1P MGC163277 MGC163279 Protein kinase/endoribonuclease RGD1559716 Serine/threonine protein kinase/endoribonuclease IRE1], [ERN1; ERN1; IRE1; IRE1P; IRE1a; hIRE1p; hIRE1p; IRE1a] |
Gene, Accession # | [IRE1], Gene ID: 2081, NCBI: O75460.2, UniProt: O75460 |
Catalog # | MBS540804 |
Price | $390 |
Order / More Info | IRE1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |