Edit |   |
---|---|
Antigenic Specificity | Human CD49e |
Clone | monoclonal |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG2b |
Format | affinity purified |
Size | 0.1 mg |
Concentration | 100ug/200ul |
Applications | Flow Cytometry (FC/FACS) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: Human CD49e. CD49e is the integrin beta5 chain, a 135/25 kDa heterodimer, that associates noncovalently with CD29, the integrin beta1 subunit, to form the beta5beta1 very late antigen-5 (VLA-5) complex, a very well established fibronectin receptor that is expressed on many cell types, including thymocytes, T cells, monocytes and platelets. Expression of the VLA-5 heterodimer is increased on activated and memory T cells. It is also found on very early B cells and on activated B lymphocytes. CD49e/CD2-mediated binding to fibronectin provides a costimulatory signal to T cells. It also enhances FcgammaR-and complement receptor-mediated phagocytosis, and is involved in monocyte migration into extracellular tissues. |
Immunogen | n/a |
Other Names | [CD49e-VLA-5] |
Gene, Accession # | [CD49e] |
Catalog # | MBS4152202 |
Price | $445 |
Order / More Info | Human CD49e Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |