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Antigenic Specificity | GSK3A (Center) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | mouse, rat (predicted reactivity: human, Xenopus) |
Isotype | n/a |
Format | purified |
Size | 0.08 mL, 0.4 mL |
Concentration | vial concentration: 0.5 |
Applications | Western Blot (WB), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This GSK3A antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 348-382 amino acids from the Central region of human GSK3A. Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1. Requires primed phosphorylation of the majority of its substrates. Contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. Regulates glycogen metabolism in liver, but not in muscle. May also mediate the develop |
Immunogen | n/a |
Other Names | [Glycogen synthase kinase-3 alpha; GSK-3 alpha; Serine/threonine-protein kinase GSK3A; GSK3A] |
Gene, Accession # | [GSK3A], Gene ID: 2931, NCBI: NP_063937.2, UniProt: P49840 |
Catalog # | MBS9208349 |
Price | $165, $370 |
Order / More Info | GSK3A (Center) Antibody from MYBIOSOURCE INC. |
Product Specific References | He X.,et al.Submitted (MAR-1995) to the EMBL/GenBank/DDBJ databases. Hoshino T.,et al.Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases. Grimwood J.,et al.Nature 428:529-535(2004). Nikoulina S.E.,et al.Diabetes 49:263-271(2000). Phiel C.J.,et al.Nature 423:435-439(2003). |