MDC1 Antibody from MYBIOSOURCE INC.

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Antigenic SpecificityMDC1
Clone[P2B11]
Host SpeciesMouse
Reactive Specieshuman, mouse, bovine, chimpanzee
IsotypeIgG1
FormatAPC-Cy7 conjugate
Size0.1 mg
Concentration1 mg/ml
ApplicationsWestern Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)
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DescriptionDetects ~184 kDa. This antibody recognizes MDC1 at and around the N-terminus. MDC1, mediator of DNA damage checkpoint protein 1, plays a role in checkpoint mediated cell cycle arrest in response to DNA damage, within S phase and G2/M. It is also thought to act as a scaffold protein during recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage that are marked by phosphorylation of histone H2A.X on S139.
ImmunogenImmunogen: GST-tagged recombinant protein corresponding to mouse MDC1 at and around the N-terminus
Other Names[Mouse Mouse MDC1 IgG1; MDC1 : APC/Cy7; Nuclear factor with BRCT domains1; mediator of DNA damage checkpoint 1]
Gene, Accession #[MDC1], Gene ID: 240087, NCBI: NP_001010833.2, UniProt: Q5PSV9
Catalog #MBS8002560
Price$495
Order / More InfoMDC1 Antibody from MYBIOSOURCE INC.
Product Specific References1. Lou Z., et al. (2004) J Biol Chem. 279(45): 46359-46362. 2. Luo K., Yuan J, Lou Z. (2011) J Biol Chem. 286(32): 28192-28199. 3. Strauss C., Halevy T., Macarov M., Argaman L., and Goldbery M. (2011) DNA Repair (Amst.). 10(8): 806-814. 4. Wilson K.A., et al. (2011) Mol Cancer Res. 9(6): 766-781.
MYBIOSOURCE INC.
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166

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