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Antigenic Specificity | MDC1 |
Clone | [P2B11] |
Host Species | Mouse |
Reactive Species | human, mouse, bovine, chimpanzee |
Isotype | IgG1 |
Format | APC-Cy7 conjugate |
Size | 0.1 mg |
Concentration | 1 mg/ml |
Applications | Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Detects ~184 kDa. This antibody recognizes MDC1 at and around the N-terminus. MDC1, mediator of DNA damage checkpoint protein 1, plays a role in checkpoint mediated cell cycle arrest in response to DNA damage, within S phase and G2/M. It is also thought to act as a scaffold protein during recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage that are marked by phosphorylation of histone H2A.X on S139. |
Immunogen | Immunogen: GST-tagged recombinant protein corresponding to mouse MDC1 at and around the N-terminus |
Other Names | [Mouse Mouse MDC1 IgG1; MDC1 : APC/Cy7; Nuclear factor with BRCT domains1; mediator of DNA damage checkpoint 1] |
Gene, Accession # | [MDC1], Gene ID: 240087, NCBI: NP_001010833.2, UniProt: Q5PSV9 |
Catalog # | MBS8002560 |
Price | $495 |
Order / More Info | MDC1 Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Lou Z., et al. (2004) J Biol Chem. 279(45): 46359-46362. 2. Luo K., Yuan J, Lou Z. (2011) J Biol Chem. 286(32): 28192-28199. 3. Strauss C., Halevy T., Macarov M., Argaman L., and Goldbery M. (2011) DNA Repair (Amst.). 10(8): 806-814. 4. Wilson K.A., et al. (2011) Mol Cancer Res. 9(6): 766-781. |