CDK4 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | CDK4 |
| Clone | [1529CT850.162.73] |
| Host Species | Mouse |
| Reactive Species | human, mouse |
| Isotype | IgG2a, kappa |
| Format | unconjugated |
| Size | 0.05 mL, 0.2 mL |
| Concentration | n/a |
| Applications | Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This CDK4 antibody is generated from a mouse immunized with a recombinant protein. Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity |
| Immunogen | n/a |
| Other Names | [Purified Mouse (Mab); Cyclin-dependent kinase 4; Cell division protein kinase 4; PSK-J3; CDK4] |
| Gene, Accession # | [CDK4], Gene ID: 1019, NCBI: NP_000066.1, UniProt: P11802 |
| Catalog # | MBS9215557 |
| Price | $165, $370 |
| Order / More Info | CDK4 Antibody from MYBIOSOURCE INC. |
| Product Specific References | Hanks S.K.,et al.Submitted (FEB-1987) to the EMBL/GenBank/DDBJ databases.Elkahloun A.G.,et al.Genomics 42:295-301(1997).Wolfel T.,et al.Science 269:1281-1284(1995).Zuo L.,et al.Nat. Genet. 12:97-99(1996).Ota T.,et al.Nat. Genet. 36:40-45(2004). |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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http://www.MyBioSource.com
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