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Antigenic Specificity | PDL-1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antigen-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PDL-1 and PDL-2. PDL-1 is a B7-related protein that inhibits cell-mediated immune responses by reducing the secretion of IL-2 and IL-10 from memory T cells. This suggests that PDL-1 may be useful in reducing allogenic CD4+ memory T-cell responses to endothelial cells, thereby reducing the likelihood of host immune responses to allografts. At least two isoforms of |
Immunogen | Immunogen Type: Peptide Immunogen Description: Raised against a 17 amino acid peptide from near the center of human PDL-1. |
Other Names | [PDL-1, Programmed cell death 1 ligand-1, programmed death ligand 1, PD-L1, B7-H1] |
Gene, Accession # | [PDL-1], Gene ID: 29126, NCBI: NP_054862 |
Catalog # | MBS9410529 |
Price | $320 |
Order / More Info | PDL-1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |