Edit |   |
---|---|
Antigenic Specificity | CD274 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.1 mL |
Concentration | 1.0 mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous level of total CD274 protein. Programmed cell death ligand 1(CD274, or B7-H1, PD-L1), is the first member of B7 family to be discovered. B7 family molecules are type I transmembrane proteins belonging to the immunoglobulin superfamily. In concert with their CD28 family receptors, the B7s are key regulators of the adaptive immune response. CD274 is suggested a negative regulator of T and B cell, and play important role in mediating tolerance of lymphocytes to self-antigens. It also involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner. |
Immunogen | Immunogen Type: Recombinant Protein Immunogen Description: Recombinant protein of human CD274. |
Other Names | [B7-H; B7H1; MGC142294; MGC142296; PD-L1] |
Gene, Accession # | [CD274], Gene ID: 29126, NCBI: NP_001254635.1, UniProt: Q9NZQ7 |
Catalog # | MBS9405493 |
Price | $255 |
Order / More Info | CD274 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |