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Antigenic Specificity | REA |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.1 mg |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC) Paraffin, Immunocytochemistry (ICC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Description: Rabbit IgG polyclonal antibody for Prohibitin-2(PHB2) detection. Tested with WB, IHC-P, ICC in Human, Mouse, Rat. Background: PHB2(Prohibitin 2), also called Repressor of Estrogen Receptor Activity(REA), is a protein that in humans is encoded by the PHB2 gene. The International Radiation Hybrid Mapping Consortium mapped the PHB2 gene to chromosome 12. Montano et al.(1999) showed that REA enhanced the potency of a dominant-negative ER-alpha mutant and antiestrogens as suppressors of ER-alpha activity in Chinese hamster ovary cells. When coexpressed with wildtype ER-alpha or ER-beta(ESR2), REA suppressed activation of a reporter gene in a dose-dependent manner. REA had no effect on reporter activity in the absence of liganded ER, |
Immunogen | Immunogen: A synthetic peptide corresponding to a sequence in the middle region of human REA (111-128aa RPNAQELPSMYQRLGLDY), identical to the related rat and mouse sequences. |
Other Names | [Prohibitin-2; prohibitin 2; B cell receptor associated protein BAP37; B-cell associated protein; B-cell receptor-associated protein BAP37; Bap 37; BAP; Bap37; BCAP 37; BCAP37; D prohibitin; D-prohibitin; MGC117268; p22; PHB 2; PHB2; PHB2_HUMAN; PNAS 141; PNAS141; Prohibitin 2; Prohibitin-2; Prohibitin2; Repressor of Estrogen Receptor Activity], [PHB2; PHB2; BAP; REA; p22; Bap37; BCAP37; PNAS-141] |
Gene, Accession # | [PHB2], Gene ID: 11331, NCBI: Q99623.2, UniProt: Q99623 |
Catalog # | MBS176293 |
Price | $315 |
Order / More Info | REA Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |