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Antigenic Specificity | PLCgamma2 |
Clone | [5H12-G10-C8] |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG2b |
Format | unconjugated |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Entrez Summary: The protein encoded by this gene is a transmembrane signaling enzyme that catalyzes the conversion of 1-phosphatidyl-1D-myo-inositol 4, 5-bisphosphate to 1D-myo-inositol 1, 4, 5-trisphosphate (IP3) and diacylglycerol (DAG) using calcium as a cofactor. IP3 and DAG are second messenger molecules important for transmitting signals from growth factor receptors and immune system receptors across the cell membrane. Mutations in this gene have been found in autoinflammation, antibody deficiency, and immune dysregulation syndrome and familial cold autoinflammatory syndrome 3. [provided by RefSeq, Mar 2014]. UniPort Summary Function: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1, 4, 5-trisphosph |
Immunogen | Immunogen: Synthesized peptide of human PLCG2 (AA: phospho-Tyrosine 753 of human Phospholipase Cg2 (cERDINSLpYDVSRMYV)). Sequence Similarities: Contains 1 SH3 domain. |
Other Names | [FCAS3; APLAID; PLC-IV; PLC-gamma-2], [PLCG2; FCAS3; APLAID; PLC-IV; PLC-gamma-2] |
Gene, Accession # | [PLCgamma2], Gene ID: 5336, NCBI: NP_002652.2, UniProt: P16885 |
Catalog # | MBS476791 |
Price | $335 |
Order / More Info | PLCgamma2 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |