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Antigenic Specificity | TEAD2 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.05 mL, 0.1 mL |
Concentration | 1.0 mg/ml |
Applications | Immunohistochemistry (IHC), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous levels of total TEAD2 protein. Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT |
Immunogen | Immunogen Type: Peptide Immunogen Description: Synthesized peptide derived from internal of human TEAD2. |
Other Names | [TEA domain family member 2; TEAD-2] |
Gene, Accession # | [TEAD2], Gene ID: 8463, NCBI: NP_001243587.1, UniProt: Q15562 |
Catalog # | MBS9403948 |
Price | $200, $255 |
Order / More Info | TEAD2 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |