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Antigenic Specificity | Phospho-PBK/TOPK (Ser58) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | humanpredicted: porcine, bovine, horse, sheep, rabbit, dog, chicken, Xenopus |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.05 mL, 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), Peptide ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: Phospho-PBK/TOPK (Ser58) Antibody detects endogenous levels of PBK/TOPK only when phosphorylated at Ser58. Description: Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage.Post Translational Modifications: Phosphorylated; in a cell-cycle dependent manner at mitosis.Subunit Structure: Interacts with DLG1 and TP53.Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily. |
Immunogen | Immunogen: A synthesized peptide derived from human PBK/TOPK around the phosphorylation site of Ser58. Tissue Specificity: Expressed in the testis and placenta. In the testis, restrictedly expressed in outer cell layer of seminiferous tubules. |
Other Names | [Cancer/testis antigen 84; CT84; Epididymis luminal protein 164; FLJ14385; HEL164; Lymphokine activated killer T cell originated protein kinase; Lymphokine-activated killer T-cell-originated protein kinase; MAPKK like protein kinase; MAPKK-like protein kinase; Nori 3; Nori-3; Nori3; PBK; PDZ binding kinase; PDZ-binding kinase; Serine/threonine protein kinase; Spermatogenesis related protein kinase; Spermatogenesis-related protein kinase; SPK; T LAK cell originated protein kinase; T-LAK cell-originated protein kinase; TOPK; TOPK_HUMAN] |
Gene, Accession # | [PBK/TOPK], Gene ID: 55872, NCBI: NP_060962.2, UniProt: Q96KB5 |
Catalog # | MBS9610794 |
Price | $225, $280, $340 |
Order / More Info | Phospho-PBK/TOPK (Ser58) Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |