Phospho-CHEK2-T68 Antibody from MYBIOSOURCE INC.

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Antigenic SpecificityPhospho-CHEK2-T68
Clonepolyclonal
Host SpeciesRabbit
Reactive Specieshuman
Isotypen/a
Formataffinity purified
Size0.1 mL
Concentrationn/a
ApplicationsWestern Blot (WB)
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DescriptionIn response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DN
ImmunogenImmunogen: A phospho specific peptide corresponding to residues surrounding T68 of human CHEK2 Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Other Names[CDS1; CHK2; HuCds1; LFS2; PP1425; RAD53; hCds1]
Gene, Accession #[CHEK2-T68], Gene ID: 11200, NCBI: NP_001005735.1, UniProt: O96017
Catalog #MBS8537025
Price$300
Order / More InfoPhospho-CHEK2-T68 Antibody from MYBIOSOURCE INC.
Product Specific Referencesn/a
MYBIOSOURCE INC.
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166

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