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Antigenic Specificity | Sumo2/3 |
Clone | monoclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.03 mg, 0.1 mg, 0.1 mg |
Concentration | n/a |
Applications | Immunofluorescence (IF), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2, CBX4 or ZNF451 (PubMed: 26524494). This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins (PubMed: 18408734, PubMed: 18538659, P |
Immunogen | Immunogen: A synthesized peptide derived from human Sumo2/3. Subcellular Localization: Nucleus. Nucleus, PML body. Tissue Specificity: Broadly expressed. |
Other Names | [Small ubiquitin-related modifier 2; SUMO-2; HSMT3; SMT3 homolog 2; SUMO-3; Sentrin-2; Ubiquitin-like protein SMT3B; Smt3B; SUMO2; SMT3B; SMT3H2], [SUMO2; SUMO2; HSMT3; SMT3B; SUMO3; Smt3A; SMT3H2; Smt3B] |
Gene, Accession # | [SUMO2], Gene ID: 6613, NCBI: NP_001005849.1, UniProt: P61956 |
Catalog # | MBS179621 |
Price | $160, $340, $340 |
Order / More Info | Sumo2/3 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |