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Antigenic Specificity | VEGI |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | Protein A purified |
Size | 0.1 mg |
Concentration | 1ug/ul |
Applications | Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | VEGI is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. An additional isoform encoded by an alternatively spliced transcript variant has been reported but the sequence of this transcript has not been determined |
Immunogen | Immunogen: Ni-NTA purified truncated recombinant VEGI expressed in E Coli strain BL21 (DE3) |
Other Names | [vascular endothelial cell growth inhibitor; Tumor necrosis factor ligand superfamily member 15; tumor necrosis factor ligand superfamily member 15; tumor necrosis factor superfamily member 15; TNF ligand-related molecule 1; Vascular endothelial cell growth inhibitor], [TNFSF15; TNFSF15; TL1; TL1A; VEGI; TNLG1B; VEGI192A; TL1; VEGI] |
Gene, Accession # | [VEGI], Gene ID: 9966, NCBI: AAD08783.1 |
Catalog # | MBS418214 |
Price | $445 |
Order / More Info | VEGI Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. kang YJ et.al Cytokine. 2005 Mar 7;29 (5):229-35 2. Prehn JL et.al Clin Immunol. 2004 Jul;112 (1):66-77. |