TLR4/MD-2, Mouse Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | TLR4/MD-2, Mouse |
| Clone | MTS510 |
| Host Species | Rat |
| Reactive Species | mouse |
| Isotype | IgG2a |
| Format | unconjugated |
| Size | 0.1 mg |
| Concentration | n/a |
| Applications | F, Flow Cytometry (FC/FACS), FS, Immunoprecipitation (IP) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Product Description: The monoclonal antibody MTS510 reacts with the Toll-like receptor 4 (TLR4, CD284) that is associated with MD2. TLRs are expressed by various cells of the immune system, such as macrophages and dendritic cells. TLRs are class I receptors, with a single alpha-helix that spans the cell membrane. They recognize and respond to molecules derived from bacterial, viral and fungal pathogens, such as lipopolysaccharide (LPS) from the outer membrane of Gram negative bacteria, peptidoglycan fragments from bacterial cell walls and single-stranded and double-stranded RNA from viruses. Toll-like receptor 4 (TLR4; CD284) has been identified, next to MD-2 and CD14, as a receptor that is central to the innate immune response to LPS of Gr |
| Immunogen | Immunogen: Ba/F3 cells expressing mouse TLR4 and MD-22 |
| Other Names | n/a |
| Gene, Accession # | [TLR4/MD-2] |
| Catalog # | MBS584221 |
| Price | $420 |
| Order / More Info | TLR4/MD-2, Mouse Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Nomura, F et al ; Cutting edge: Endotoxin tolerance in mouse peritoneal macrophages correlate with down-regulation of surface toll-like receptor 4 expression. J Immunol 2000, 164: 3476 2. Akashi, S et al; Cutting edge: Cell surface expression and lipopolysaccharide signalling via the toll-like receptor 4-MD-2 complex on mouse peritoneal macrophages. J Immunol 2000, 164: 3471 3. Sato, S et al; Synergy and cross-tolerance between toll-like receptor (TLR)2- and TLR4-mediated signaling pathways. J Immunol 2000, 165: 7096 4. Ortega-Cava, C et al; Strategic compartmentalization of toll-like receptor 4 in the mouse gut. J Immunol 2003, 170: 3977 5. Tsujimoto, H. A critical role of CpG motifs in a murine peritonitis model by their binding to highly expressed toll-like receptor-9 on liver NTK cells. J hepatology 2006, 45: 836 6. Cook,C et al. Lipopolysaccharide, Tumor Necrosis Factor alpha, or Interleukin-1β triggers reactivation of latent CMV in immunocompetent mice. J virology 2006, 80: 9151 7. Tsukumo_D et al. Loss-of-function mutation in Toll-like receptor 4 prevents diet-induced obesity and insulin resistance. Diabetes 2007, 56: 1986 8. Burton, O et al. Importance of TLR2 in the direct response of T lymphocytes to Schistosoma mansoni antigens. Eur J Immunol 2010, 40: 2221 |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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