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Antigenic Specificity | POLH |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.03 mL, 0.1 mL, 0.2 mL |
Concentration | 1 mg/ml |
Applications | Western Blot (WB), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous levels of POLH protein. POLH encodes a member of the Y family of specialized DNA polymerases. It copies undamaged DNA with a lower fidelity than other DNA-directed polymerases. However, it accurately replicates UV-damaged DNA; when thymine dimers are present, this polymerase inserts the complementary nucleotides in the newly synthesized DNA, thereby bypassing the lesion and suppressing the mutagenic effect of UV-induced DNA damage. This polymerase is thought to be involved in hypermutation during immunoglobulin class switch recombination. Mutations in this gene result in XPV, a variant type of xeroderma pigmentosum. Several transcript variants encoding different isoforms have been found for this gene. |
Immunogen | Immunogen: Synthesized peptide derived from part region of human POLH protein |
Other Names | [Rabbit POLH; DNA polymerase eta; RAD30 homolog A; Xeroderma pigmentosum variant type protein] |
Gene, Accession # | [POLH], Gene ID: 5429, NCBI: Q9Y253.1, UniProt: Q9Y253 |
Catalog # | MBS9710513 |
Price | $130, $220, $325 |
Order / More Info | POLH Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |