Dnmt3a Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | Dnmt3a |
| Clone | [1823CT281.43.36] |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG1,k |
| Format | unconjugated |
| Size | 0.05 mL, 0.2 mL |
| Concentration | n/a |
| Applications | Western Blot (WB), ELISA (EIA) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This Dnmt3a antibody is generated from a mouse immunized with a recombinant protein of human Dnmt3a. Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the |
| Immunogen | n/a |
| Other Names | [DNA (cytosine-5)-methyltransferase 3A; Dnmt3a; 2.1.1.37; DNA methyltransferase HsaIIIA; DNA MTase HsaIIIA; M.HsaIIIA; DNMT3A] |
| Gene, Accession # | [DNMT3A], Gene ID: 1788, NCBI: NP_001307821.1, UniProt: Q9Y6K1 |
| Catalog # | MBS9230981 |
| Price | $165, $370 |
| Order / More Info | Dnmt3a Antibody from MYBIOSOURCE INC. |
| Product Specific References | Xie S.,et al.Gene 236:87-95 (1999). Chen T.,et al.J. Biol. Chem. 277:38746-38754 (2002). Kim G.-D.,et al.EMBO J. 21:4183-4195 (2002). Hillier L.W.,et al.Nature 434:724-731 (2005). Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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