Human ERBB2 / HER2 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | Human ERBB2 / HER2 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, monkey, mouse, rat, dog, hamster, horse, porcine. predicted reactivity: bat, bovine |
| Isotype | n/a |
| Format | Protein A purified |
| Size | 0.05 mg |
| Concentration | 1 mg/ml |
| Applications | Immunohistochemistry (IHC - Paraffin; IHC - Frozen), Western Blot (WB), Immunoprecipitation (IP) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Recognizes c-erbB-2 (185kD), but not c-erbB-1(EGF-R), c-erbB-3 or c-erbB-4. A tyrosine kinase receptor in the EGF-receptor family. ErbB2 does not bind ligand on its own, but acts as an amplifier in heterodimers with ErbB1, (EGFR), ErbB3, or ErbB4. Amplification of the ErbB2 gene and overexpression of ErbB2 protein is associated with breast cancer (~25% of cases), and anti-ErbB2 therapeutics (e. g. Herceptin, an anti-ErbB2 monoclonal antibody) are sometimes effective in treating these cases. Overexpression of ErbB2 has also been indicated as a factor in prostate cancer. |
| Immunogen | Immunogen: Antibody was raised against a KLH-linked peptide (AENPEYLGLDVPV) corresponding to aa1243-1255 from the human c-erbB-2/HER-2/neu oncoprotein. Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Rat, Hamster, Panda, Dog, Horse, Pig (100%); Elephant, Bat, Bovine (92%); Opossum (85%). Epitope: aa1243-1255 |
| Other Names | [ERBB2 / HER2 (aa1243-1255) IHC-plus; ERBB2; C-erb B2/neu protein; CD340; HER2; Herstatin; MLN 19; HER-2; Neu; NGL; Proto-oncogene c-ErbB-2; Proto-oncogene Neu; CD340 antigen; MLN19; p185erbB2; TKR1; Human ERBB2; HER2], [HER2] |
| Gene, Accession # | [ERBB2], Gene ID: 2064, NCBI: NP_004439.2, UniProt: P04626 |
| Catalog # | MBS241896 |
| Price | $530 |
| Order / More Info | Human ERBB2 / HER2 Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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