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Antigenic Specificity | TANK |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mg |
Concentration | 1 mg/mL |
Applications | ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | TANK Antibody: TANK was initially identified as a novel TRAF-interacting protein that regulated TRAF-mediated signal transduction. Specifically, ligand binding by surface receptors in the tumor necrosis factor (TNF) receptor and Toll/interleukin-1 (IL-1) receptor families lead to the formation of a TRAF/TANK complex that mediates the activation of the transcription factor NF-κB. This activation of NF-κB occurs through an association with the kinases IKKε and TBK1. More recently, it was shown that these proteins can then form a complex with NEMO, a protein that regulates the activity of the IκB complex. This suggests that in addition to the possibility that TBK1 and IKKε activate the IKKs, the association with the IK |
Immunogen | Immunogen: TANK antibody was raised against a 14 amino acid synthetic peptide from near the amino terminus of human TANK. Buffer: TANK Antibody is supplied in PBS containing 0.02% sodium azide. |
Other Names | [TANK; ITRAF; TRAF2; I-TRAF; ITRAF; TRAF family member-associated NF-kappa-B activator; TRAF-interacting protein; TRAF family member-associated NFKB activator], [TANK; TANK; ITRAF; TRAF2; I-TRAF; ITRAF; TRAF2; I-TRAF] |
Gene, Accession # | [TANK], Gene ID: 10010, NCBI: NP_004171, UniProt: Q92844 |
Catalog # | MBS150385 |
Price | $375 |
Order / More Info | TANK Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |