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Antigenic Specificity | CDK5R1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.05 mL, 0.1 mL |
Concentration | 1.0 mg/ml |
Applications | Western Blot (WB), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous levels of total CDK5R1 protein. p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-ARNTL/BMAL1 heterodimer in association with altered stability and subcellular distribution.Tsai L.-H., Nature 371:419-423(1994).Patrick G.N., Nature 402:615-622(1999).Kesavapany S., J. Neurosci. 24:4421-4431(2004). |
Immunogen | Immunogen Type: Peptide Immunogen Description: Synthesized peptide derived from internal of human CDK5R1. |
Other Names | [CD5R; CD5R1; CDK5 activator 1; CDK5R; Cyclin-dependent kinase 5 activator 1 precursor] |
Gene, Accession # | [CDK5R1], Gene ID: 8851, NCBI: NP_003876.1, UniProt: Q15078 |
Catalog # | MBS9404625 |
Price | $200, $255 |
Order / More Info | CDK5R1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |