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Antigenic Specificity | CD11b/MAC-1 (Microglial Marker) |
Clone | [ITGAM/3340] |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG2a, kappa |
Format | purified |
Size | 0.02 mg (With BSA & Azide at 0.2mg/ml), 0.1 mg (With BSA & Azide at 0.2mg/ml), 0.1 mg (Without BSA & Azide at 1mg/ml) |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC) Paraffin |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: CD11b is a cell adhesion molecule that acts as a receptor for cell surface ligands such as intracellular adhesion molecules (ICAMs) or soluble ligands. Integrins are heterodimeric proteins that contain an a chain and b chain. Integrin aM combines with the Integrin '2 to form a leukocyte-specific integrin referred to as macrophage receptor 1 (Mac-1), or inactivated-C3b (iC3b) receptor 3 (CR3). Integrin aM/'2 is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. The protein CD11b has been implicated in the various adhesion-related interactions of cells such as monocytes, macrophages, natural killer (NK) cells, and granulocytes. It is part |
Immunogen | Immunogen: Recombinant fragment (around aa941-1074) of human ITGAM protein (exact sequence is proprietary) |
Other Names | [CD18; CD49d; Cell surface glycoprotein MAC-1 subunit alpha; Complement Component Receptor 3 Alpha; CR3 Alpha Chain (CR3A); Integrin alpha-M; Integrin beta 2 alpha subunit; Leukocyte adhesion receptor MO1; Ly-40; MAC1A; Macrophage antigen alpha polypeptide; MO1A; Neutrophil adherence receptor alpha M subunit] |
Gene, Accession # | [CD11b/MAC-1], Gene ID: 3684, NCBI: NP_001139280.1, UniProt: P11215 |
Catalog # | MBS4381023 |
Price | $190, $340, $340 |
Order / More Info | CD11b/MAC-1 (Microglial Marker) Antibody from MYBIOSOURCE INC. |
Product Specific References | Springer T, et al. 1978. Eur. J. Immunol. 8:539 |