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Antigenic Specificity | PRDM16 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mg |
Concentration | 1 mg/mL |
Applications | ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | PRDM16 Antibody: PRDM16 is a zinc finger transcription factor and contains an N-terminal PR domain. The reciprocal translocation t(1;3)(p36;q21) occurs in a subset of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). This gene is located near the 1p36.3 breakpoint and has been shown to be specifically expressed in the t(1:3)(p36, q21)-positive MDS/AML. The translocation results in the overexpression of a truncated version of this protein that lacks the PR domain, which may play an important role in the pathogenesis of MDS and AML. Recent studies have shown that PRDM16 normally acts as a Smad3 binding protein that may be important for the development of orofacial structures through modulation of the TGF-beta signaling pathway. |
Immunogen | Immunogen: PRDM16 antibody was raised against a 17 amino acid synthetic peptide from near the carboxy terminus of human PRDM16. Buffer: PRDM16 Antibody is supplied in PBS containing 0.02% sodium azide. |
Other Names | [PRDM16; MEL1; LVNC8; PFM13; CMD1LL; KIAA1675; MEL1; PR domain zinc finger protein 16; PR domain-containing protein 16; PR domain containing 16], [PRDM16; PRDM16; MEL1; LVNC8; PFM13; CMD1LL; KIAA1675; MEL1; PFM13; MDS1/EVI1-like gene 1] |
Gene, Accession # | [PRDM16], Gene ID: 63976, NCBI: CAH71530, UniProt: Q9HAZ2 |
Catalog # | MBS150905 |
Price | $375 |
Order / More Info | PRDM16 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |