AML1 (Phospho-Ser435) Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | AML1 (Phospho-Ser435) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | epitope affinity purified |
| Size | 0.05 mL, 0.1 mL |
| Concentration | 1.0 mg/ml |
| Applications | Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | The antibody detects endogenous levels of AML1 only when phosphorylated at serine 435. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL-3 and GM-CSF promoters. The alpha subunit binds DNA and appears to have a role in the development of normal hematopoiesis. Isoform AML-1L interferes with the transactivation activity of RUNX1. Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the mouse BLK promoter. Inhibits MYST4-dependent transcriptional activation.Miyoshi H., Proc. Natl. Acad. Sci. U.S.A. 88:10431-10434(1991).Sacchi N., Genes Chromosomes Cancer 11:226-236(1994).Nucifo |
| Immunogen | Immunogen Type: Peptide-KLH Immunogen Description: Peptide sequence around phosphorylation site of Serine 435(S-N-S(p)-P-T) derived from Human AML1. |
| Other Names | [Acute myeloid leukemia 1 protein; CBFA2; CBFA2; alpha 2 subunit; RUNX1] |
| Gene, Accession # | [AML1], Gene ID: 861, NCBI: NP_001001890.1, UniProt: Q01196 |
| Catalog # | MBS9403427 |
| Price | $200, $255 |
| Order / More Info | AML1 (Phospho-Ser435) Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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