Human Bad Antibody from MYBIOSOURCE INC.
Search, find, compare suppliers for anti-Human Bad antibody, protein, ELISA kits.
| Edit | |
|---|---|
| Antigenic Specificity | Human Bad |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | affinity purified |
| Size | 0.05 mL, 0.1 mL, 0.2 mL |
| Concentration | 1mg/ml |
| Applications | Western Blot (WB), Immunohistochemistry (IHC) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Bad is a proapoptotic member of the Bcl-2 family that promotes cell death by displacing Bax from binding to Bcl-2 and Bcl-xL (1,2). Survival factors, such as IL-3, inhibit the apoptotic activity of Bad by activating intracellular signaling pathways that result in the phosphorylation of Bad at Ser112 and Ser136 (2). Phosphorylation at these sites promotes binding of Bad to 14-3-3 proteins to prevent an association between Bad with Bcl-2 and Bcl-xl (2). Akt phosphorylates Bad at Ser136 to promote cell survival (3,4). Bad is phosphorylated at Ser112 both in vivo and in vitro by p90RSK (5,6) and mitochondria-anchored PKA (7). Phosphorylation of Ser155 in the BH3 domain by PKA plays a critical role in blocking the dimerization of Bad and Bcl-xL |
| Immunogen | Immunogen: A synthetic peptide of human Bad |
| Other Names | [Bad Rabbit pab], [Bcl2 antagonist of cell death; BAD; Bcl-2-binding component 6; Bcl-XL/Bcl-2-associated death promoter; Bcl-2-like 8 protein; BAD; BBC6; BCL2L8] |
| Gene, Accession # | [Bad], Gene ID: 572, NCBI: NP_116784, UniProt: Q92934 |
| Catalog # | MBS125400 |
| Price | $200, $275, $430 |
| Order / More Info | Human Bad Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Yang, E. et al. (1995) Cell 80, 285-291. 2. Zha, J. et al. (1996) Cell 87, 619-628. 3. Datta, S.R. et al. (1997) Cell 91, 231-241. 4. Peso, L. et al. (1997) Science 278, 687-689. 5. Bonni, A. et al. (1999) Science 286, 1358-1362. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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