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Antigenic Specificity | CIRBP (C-term), 145-172 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human (predicted reactivity: hamster, mouse, rat) |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.08 mL, 0.4 mL |
Concentration | vial concentration: 0.5 |
Applications | Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This CIRBP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 145-172 amino acids from the C-terminal region of human CIRBP. CIRBP is cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. It acts as a translational activator and seems to play an essential role in cold-induced suppression of cell proliferation. It binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. This protein acts as a translational repressor (By similarity) and promotes assembly of stress granules (SGs), when overexpressed. |
Immunogen | n/a |
Other Names | [Cold-inducible RNA-binding protein; A18 hnRNP; Glycine-rich RNA-binding protein CIRP; CIRBP; A18HNRNP; CIRP] |
Gene, Accession # | [CIRBP], Gene ID: 1153, NCBI: NP_001271.1, UniProt: Q14011 |
Catalog # | MBS9215270 |
Price | $165, $370 |
Order / More Info | CIRBP (C-term), 145-172 Antibody from MYBIOSOURCE INC. |
Product Specific References | Colinge J., et.al., Submitted (OCT-2008) to UniProtKB. Yang R.,et.al., Nucleic Acids Res. 34:1224-1236(2006). |