Edit |   |
---|---|
Antigenic Specificity | SMAD2/3 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Polyclonal antibody to detect endogenous levels of SMAD2/3 in human; mouse and rat. Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and; on formation of the SMAD2/SMAD4 complex; activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. |
Immunogen | Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human SMAD2/3 |
Other Names | [SMAD2; MADH2; MADR2; Mothers against decapentaplegic homolog 2; MAD homolog 2; Mothers against DPP homolog 2; JV18-1; Mad-related protein 2; hMAD-2; SMAD family member 2; SMAD 2; Smad2; hSMAD2; SMAD3; MADH3; Mothers against decapentaplegic homolog 3; MAD homolog 3; Mad3; Mothers against DPP homolog 3; hMAD-3; JV15-2; SMAD family member 3; SMAD 3; Smad3; hSMAD3], [SMAD2; SMAD2; JV18; MADH2; MADR2; JV18-1; hMAD-2; hSMAD2; MADH2; MADR2; MAD homolog 2; Mothers against DPP homolog 2; hMAD-2; SMAD 2; Smad2; hSMAD2] |
Gene, Accession # | [SMAD2/3], Gene ID: 4087, NCBI: NP_001003652.1, UniProt: Q15796 |
Catalog # | MBS846092 |
Price | $375 |
Order / More Info | SMAD2/3 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |