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Antigenic Specificity | PML |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Functions via its association with PML-nuclear bodies (PML-NBs) in a wide range of important cellular processes, including tumor suppression, transcriptional regulation, apoptosis, senescence, DNA damage response, and viral defense mechanisms. Acts as the scaffold of PML-NBs allowing other proteins to shuttle in and out, a process which is regulated by SUMO-mediated modifications and interactions. Isoform PML-4 has a multifaceted role in the regulation of apoptosis and growth suppression: activates RB1 and inhibits AKT1 via interactions with PP1 and PP2A phosphatases respectively, negatively affects the PI3K pathway by inhibiting MTOR and activating PTEN, and positively regulates p53/TP53 by acting at different levels (by promoting its acet |
Immunogen | Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 300-600 of human PML (NP 150253.2). |
Other Names | [MYL; RNF71; PP8675; TRIM19] |
Gene, Accession # | [PML], Gene ID: 5371, NCBI: NP_002666.1, UniProt: P29590 |
Catalog # | MBS8544293 |
Price | $280 |
Order / More Info | PML Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |