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Antigenic Specificity | MAP2K1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.1 mL |
Concentration | 1.0 mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous level of total MAP2K1 protein. MAP2K1 and MEK2, also called MAPK or Erk kinases, are dual-specificity protein kinases that function in a mitogen activated protein kinase cascade controlling cell growth and differentiation (1-3). Activation of MAP2K1 and MEK2 occurs through phosphorylation of two serine residues at positions 217 and 221, located in the activation loop of subdomain VIII, by Raf-like molecules. MAP2K1/2 is activated by a wide variety of growth factors and cytokines and also by membrane depolarization and calcium influx (1-4). Constitutively active forms of MAP2K1/2 are sufficient for the transformation of NIH/3T3 cells or the differentiation of PC-12 cells (4). MEK activates p44 and p42 MAP kina |
Immunogen | Immunogen Type: Peptide Immunogen Description: A synthetic peptide of human MAP2K1. |
Other Names | [MAP2K1; MAPKK1; MEK1; MKK1; PRKMK1] |
Gene, Accession # | [MAP2K1], Gene ID: 5604, NCBI: NP_002746.1, UniProt: Q02750 |
Catalog # | MBS9402777 |
Price | $255 |
Order / More Info | MAP2K1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |