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Antigenic Specificity | ATF2 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The transcription factor ATF-2 (also called CRE-BP1) binds to both AP-1 and CRE DNA response elements and is a member of the ATF/CREB family of leucine zipper proteins (1). ATF-2 interacts with a variety of viral oncoproteins and cellular tumor suppressors and is a target of the SAPK/JNK and p38 MAP kinase signaling pathways (2-4). Various forms of cellular stress, including genotoxic agents, inflammatory cytokines, and UV irradiation, stimulate the transcriptional activity of ATF-2. Cellular stress activates ATF-2 by phosphorylation of Thr69 and Thr71 (2-4). Both SAPK and p38 MAPK have been shown to phosphorylate ATF-2 at these sites in vitro and in cells transfected with ATF-2. Mutations of these sites result in the loss of stress-induced |
Immunogen | Immunogen: Recombinant protein of human ATF2 Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Other Names | [CRE-BP1; CREB2; HB16; MGC111558; TREB7] |
Gene, Accession # | [ATF2], Gene ID: 1386, NCBI: NP_001243019.1, UniProt: P15336 |
Catalog # | MBS8527385 |
Price | $310 |
Order / More Info | ATF2 Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Abdel-Hafiz, H.A. et al. (1992) Mol. Endocrinol. 6, 2079-2089. 2. Gupta, S. et al. (1995) Science 267, 389-393. 3. van Dam, H. et al. (1995) EMBO J. 14, 1798-1811. 4. Livingstone, C. et al. (1995) EMBO J. 14, 1785-1797. |