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Antigenic Specificity | GRN |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual act |
Immunogen | Immunogen: Recombinant protein of human GRN (NP 002078.1). |
Other Names | [granulin; Granulins; progranulin; granulin precursor; Proepithelin; PEPICleaved into the following 9 chains:AcrograninParagranulinGranulin-1; Alternative name(s):; Granulin GGranulin-2; Alternative name(s):; Granulin FGranulin-3; Alternative name(s):; Granulin BGranulin-4; Alternative name(s):; Granulin AGranulin-5; Alternative name(s):; Granulin CGranulin-6; Alternative name(s):; Granulin DGranulin-7; Alternative name(s):; Granulin E] |
Gene, Accession # | [GRN], Gene ID: 2896, NCBI: AAA58617.1, UniProt: P28799 |
Catalog # | MBS8572635 |
Price | $280 |
Order / More Info | GRN Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |