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Antigenic Specificity | ALK (Anaplastic Lymphoma Kinase)/CD246 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | purified |
Size | 0.02 mg (With BSA & Azide at 0.2mg/ml), 0.1 mg (With BSA & Azide at 0.2mg/ml), 0.1 mg (Without BSA & Azide at 1mg/ml) |
Concentration | n/a |
Applications | Immunohistochemistry (IHC) Paraffin |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The wild-type anaplastic lymphoma kinase (ALK) protein is a 200kDa transmembrane receptor tyrosine kinase. Its expression is restricted to a few scattered cells in the nervous system (some glial cells and neurons, and a few endothelial cells and pericytes. The hybrid gene,NPM-ALK, created by the t(2;5)(p23;q35) chromosomal translocation encodes part of the nucleolar phosphoprotein, nucleophosmin (NPM), joined to the entire cytoplasmic portion of the anaplastic lymphoma kinase (ALK) receptor tyrosine kinase. As a consequence, the ALK gene comes under the control of the NPM promoter, which induces a permanent and ubiquitous transcription of the NPM-ALK hybrid gene, resulting in the production of a 80kDa NPM-ALK chimeric protein. This transloc |
Immunogen | Immunogen: Recombinant human ALK protein fragment (aa200-335) |
Other Names | [ALK/NPM1 fusion gene; Anaplastic lymphoma kinase Ki1; Anaplastic Lymphoma Kinase p80; anaplastic lymphoma receptor tyrosine kinase; mutant anaplastic lymphoma kinase; NBLST3; Tcrz; TFG/ALK] |
Gene, Accession # | [ALK], Gene ID: 238, NCBI: NP_004295.2, UniProt: Q9UM73 |
Catalog # | MBS4380916 |
Price | $190, $340, $340 |
Order / More Info | ALK (Anaplastic Lymphoma Kinase)/CD246 Antibody from MYBIOSOURCE INC. |
Product Specific References | Pulford K, et al. Blood 1997;89:1394-404. |