CD11/CD18, Human Antibody from MYBIOSOURCE INC.
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| Edit | |
|---|---|
| Antigenic Specificity | CD11/CD18, Human |
| Clone | 24 |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | unconjugated |
| Size | 0.1 mg |
| Concentration | n/a |
| Applications | F, Flow Cytometry (FC/FACS), FS, Immunoassay (IA), Immunoprecipitation (IP) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Product Description: The monoclonal antibody 24 recognizes an epitope of 174 kD present on leukocyte integrins, CD11/CD18 or beta 2-type integrins. The leukocyte integrins are a family of heterodimeric receptors that mediate divalent cation-dependent cellular adhesion reactions. T cells use integrins in essentially all of their functions. Integrins become active following signalling through other membrane receptors, which cause both affinity alteration and an increase in integrin clustering. The monoclonal antibody 24 recognizes a structural feature and is strictly dependent upon the presence of Mg2. The epitope is located within, or in close proximity to, the three conserved cation binding domains and therefore a measure of Mg2 bound to th |
| Immunogen | n/a |
| Other Names | n/a |
| Gene, Accession # | [CD11/CD18] |
| Catalog # | MBS584422 |
| Price | $610 |
| Order / More Info | CD11/CD18, Human Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Hogg, N et al; An anti-human monocyte/macrophage monoclonal antibody, reacting most strongly with macrophages in lymphoid tissue. Cell Immunol 1985, 92: 247 2. Dransfield, I et al; Regulated expression of Mg2 binding epitope on leukocyte integrin alpha subunits. EMBO J 1989, 8: 3759 3. Dransfield, I et al; Interaction of leukocyte integrins with ligand is necessary but not sufficient for function. J Cell Biol 1992, 116: 1527 4. Kamata, T et al; The role of the CPNKEKEC sequence in the beta(2) subunit I domain in regulation of integrin alpha(L)beta(2) (LFA-1). J Immunol 2002, 168: 2296 5. Hogg, N et al; T-cell integrins: more than just sticking points. J Cell Sci 2003, 116: 4695 |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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