EpCAM/CD326/EPG-2/SCLC-CD2 epithelial antigen Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | EpCAM/CD326/EPG-2/SCLC-CD2 epithelial antigen |
| Clone | [MOC-181] |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG2a |
| Format | unconjugated |
| Size | 0.1 mg |
| Concentration | n/a |
| Applications | Flow Cytometry (FC/FACS) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | The antibody MOC-181 is directed against human EpCAM. The antibody has been reported to react with an epitope within the first EGF-like repeat in the extracellular region of EpCAM. The epithelial cell adhesion molecule (EpCAM), also known as CD326, is a 40 kD glycoprotein that is expressed at the basolateral cell membrane of simple, pseudo-stratified and transitional epithelia of normal adult tissues. EpCAM is reported to function as a homotypic calcium-independent cell adhesion molecule but studies suggest that EpCAM is also involved in cellular processes such as cell signalling, migration, proliferation and differentiation. EpCAM is overexpressed in a wide range of human epithelial carcinomas including lung, colorectal, breast, prostate, |
| Immunogen | Source Note: MOC-181 is a mouse monoclonal IgG2a antibody derived by fusion of mouse myeloma cells with spleen cells from a mouse immunized with an extract from a small cell lung carcinoma cell line. |
| Other Names | [epithelial cell adhesion molecule; Epithelial cell adhesion molecule; epithelial cell adhesion molecule; epithelial glycoprotein 314; human epithelial glycoprotein-2; cell surface glycoprotein Trop-1; adenocarcinoma-associated antigen; tumor-associated calcium signal transducer 1; major gastrointestinal tumor-associated protein GA733-2; membrane component, chromosome 4, surface marker (35kD glycoprotein); epithelial cell adhesion molecule; Adenocarcinoma-associated antigen; Cell surface glycoprotein Trop-1; Epithelial cell surface antigen; Epithelial glycoprotein; EGP; Epithelial glycoprotein 314; EGP314; hEGP314; KS 1/4 antigen; KSA; Major gastrointestinal tumor-associated protein GA733-2; Tumor-associated calcium signal transducer 1; CD_antigen: CD326], [EPCAM; EPCAM; ESA; KSA; M4S1; MK-1; DIAR5; EGP-2; EGP40; KS1/4; MIC18; TROP1; EGP314; HNPCC8; TACSTD1; GA733-2; M1S2; M4S1; MIC18; TACSTD1; TROP1; Ep-CAM; EGP; EGP314; hEGP314] |
| Gene, Accession # | [EpCAM/CD326/EPG-2/SCLC-CD2], Gene ID: 4072, NCBI: NP_002345.2, UniProt: P16422 |
| Catalog # | MBS570321 |
| Price | $415 |
| Order / More Info | EpCAM/CD326/EPG-2/SCLC-CD2 epithelial antigen Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. De Leij L, Helrich W, Stein R, Mattes MJ. 1994. SCLC-cluster-2 antibodies detect the pancarcinoma/epithelial glycoprotein EGP-2. Int J Cancer Suppl.8:60-3.2. Kroesen BJ, McLaughlin PM, Schuilenga-Hut PH, Jacobs SC, Molema G, Helfrich W, De Leij LF. 2002. Tumor-targeted immune complex formation: effects on myeloid cell activation and tumor-directed immune cell migration.Int J Cancer.98:857-63.3. Schnell U, Cirulli V, Giepmans BN.2013. EpCAM: structure and function in health and disease. Biochim Biophys Acta.1828:1989-2001 |
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