MAP3K8 Antibody from MYBIOSOURCE INC.
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|---|---|
| Antigenic Specificity | MAP3K8 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | unconjugated |
| Size | 0.1 mg |
| Concentration | 0.62-0.65 ug/ul in antibody stabilization buffer |
| Applications | ELISA (EIA), Immunoprecipitation (IP), Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Affinity Purified Mitogen-activated protein kinase kinase kinase 8 Antibody. Required for lipopolysaccharide (LPS)-induced, TLR4-mediated activation of the MAPK/ERK pathway in macrophages, thus being critical for production of the proinflammatory cytokine TNF-alpha (TNF) during immune responses. Involved in the regulation of T-helper cell differentiation and IFNG expression in T-cells. Involved in mediating host resistance to bacterial infection through negative regulation of type I interferon (IFN) production. In vitro, activates MAPK/ERK pathway in response to IL1 in an IRAK1-independent manner, leading to up-regulation of IL8 and CCL4. Transduces CD40 and TNFRSF1A signals that activate ERK in B-cells and macrophages, and thus may play a |
| Immunogen | Immunogen: Synthetic peptide taken within amino acid region 360-470 on human MAP3K8 protein. Expression: Expressed in several normal tissues and human tumor-derived cell lines. |
| Other Names | [c COT; Cancer Osaka thyroid oncogene; COT; COT proto oncogene serine/threonine protein kinase; EST; ESTF; Ewing sarcoma transformant; FLJ10486; MEKK8; Mitogen activated protein kinase kinase kinase 8; Proto oncogene cCot; Serine/threonine-protein kinase cot; TPL 2; Tumor progression locus 2], [MAP3K8; MAP3K8; COT; EST; ESTF; TPL2; AURA2; MEKK8; Tpl-2; c-COT; COT; ESTF; TPL-2] |
| Gene, Accession # | [MAP3K8], Gene ID: 1326, NCBI: AAI13567.1, UniProt: P41279 |
| Catalog # | MBS540421 |
| Price | $390 |
| Order / More Info | MAP3K8 Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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