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Antigenic Specificity | TNPO1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates (PubMed:24753571). Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP-and GDP-bound forms of Ran between t |
Immunogen | Immunogen: A synthetic peptide corresponding to a sequence within amino acids 800 to the C-terminus of human TNPO1 (NP 002261.3). |
Other Names | [MIP; TRN; IPO2; MIP1; KPNB2] |
Gene, Accession # | [TNPO1], Gene ID: 3842, NCBI: NP_002261.3, UniProt: Q92973 |
Catalog # | MBS8547598 |
Price | $280 |
Order / More Info | TNPO1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |