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Antigenic Specificity | SNW1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Involved in transcriptional regulation. Modulates TGF-beta-mediated transcription via association with SMAD proteins, MYOD1-mediated transcription via association with PABPN1, RB1-mediated transcriptional repression, and retinoid-X receptor (RXR)-and vitamin D receptor (VDR)-dependent gene transcription in a cell line-specific manner probably involving coactivators NCOA1 and GRIP1. Is involved in NOTCH1-mediated transcriptional activation. Binds to multimerized forms of Notch intracellular domain (NICD) and is proposed to recruit transcriptional coactivators such as MAML1 to form an intermediate preactivation complex which associates with DNA-bound CBF-1/RBPJ to form a transcriptional activation complex by releasing SNW1 and redundant NOTCH |
Immunogen | Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 300-536 of human SNW1 (NP 036377.1). |
Other Names | [Bx42; SKIP; FUN20; Prp45; SKIIP; SKIP1; PRPF45; NCOA-62] |
Gene, Accession # | [SNW1], Gene ID: 22938, NCBI: NP_036377, UniProt: Q13573 |
Catalog # | MBS8549513 |
Price | $280 |
Order / More Info | SNW1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |