CDC25b (pS42) Antibody from MYBIOSOURCE INC.
Search, find, compare suppliers for anti-CDC25b (pS42) antibody, protein, ELISA kits.
| Edit | |
|---|---|
| Antigenic Specificity | CDC25b (pS42) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | epitope affinity purified |
| Size | 0.1 mg |
| Concentration | n/a |
| Applications | ELISA (EIA), Flow Cytometry (FC/FACS), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This antibody recognizes phosphorylated Serine 42 of human CDC25B protein. It does not recognize the nonphosphorylated CDC25B. Three homologues of CDC25 called CDC25A/B/C Cdc25 tyrosine phosphatases positively regulate the cell cycle by activating cyclin-dependent kinase/cyclin complexes CDK1 (CDC2). Dephosphorylation of threonine 14 and tyrosine 15 of CDK1 by CDC25 phosphatases is a key step in the activation of the CDK1-cycline B protein kinase. Of the three mammalian Cdc25 isoforms, Cdc25A is phosphorylated by genotoxic stress-activated Chk1 or Chk2, which triggers its SCFbeta-TrCP-mediated degradation. CDC25B is degraded by the proteasome. CDK1-cyclin A phosphorylation targets CDC25B for degradation and this might be an important compon |
| Immunogen | n/a |
| Other Names | n/a |
| Gene, Accession # | [CDC25b], Gene ID: 994 |
| Catalog # | MBS460387 |
| Price | $285 |
| Order / More Info | CDC25b (pS42) Antibody from MYBIOSOURCE INC. |
| Product Specific References | Veronique Baldin, et al, Phosphorylation of Human CDC25B Phosphatase by CDK1-Cyclin A Triggers Its Proteasome-dependent Degradation. The Journal of Biological Chemistry, 272, 32731-32734 (1997). |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
Profile of MYBIOSOURCE INC.
Return to Antibodies