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Antigenic Specificity | KappaB ras |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | KappaB ras-1 (kB-ras-1) and kappaB-ras-2 are two small proteins that similar to Ras-like small GTPases that associate with IkB (IkB), an inhibitor of the transcription factor NF-kB. IkB exists in two homologous forms, IkB-alpha and IkB-beta, although IkB-beta contains a unique 47-amino acid region within its ankyrin domain. While inactive IkB-alpha-NF-kB complexes can shuttle in and out of the nucleus, IkB-beta-NF-kB complexes are retained exclusively in the cytoplasm. It is suggested that kappaB-ras proteins preferentially bind to the IkB-beta form through this unique insert within the ankyrin region, thus modulating the cellular location of IkB-beta and regulating the rate of degradation of IkB-beta. This antibody detects both kappaB-ras1 |
Immunogen | Immunogen Type: Peptide Immunogen Description: Raised against a 18 amino acid peptide from near the center of human KappaB ras 1. |
Other Names | [KappaB ras, NF-kappaB inhibitor-interacting Ras like protein, kappaB-ras, NKIRAS] |
Gene, Accession # | Gene ID: 28512, NCBI: AAF34998 |
Catalog # | MBS9405411 |
Price | $320 |
Order / More Info | KappaB ras Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |