Hsp90 alpha Antibody from MYBIOSOURCE INC.
Search, find, compare suppliers for anti-Hsp90 alpha antibody, protein, ELISA kits.
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|---|---|
| Antigenic Specificity | Hsp90 alpha |
| Clone | [2G5.G3] |
| Host Species | Mouse |
| Reactive Species | human, mouse, rat |
| Isotype | IgG1 kappa |
| Format | ATTO 655 conjugate |
| Size | 0.2 mg |
| Concentration | 1mg/mL |
| Applications | Western Blot (WB), Immunoprecipitation (IP), ELISA (EIA), Immunocytochemistry (ICC), Immunohistochemistry (IHC), Immunofluorescence (IF) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Background Info: Hsp90alpha-specific (>96% alpha-specific by ELISA) Scientific Background: HSP90 is an abundantly and ubiquitously expressed heat shock protein. It is understood to exist in two principal forms alpha and beta, which share 85% sequence amino acid homology. The two isoforms of Hsp90 are expressed in the cytosolic compartment (1). Despite the similarities, HSP90alpha exists predominantly as a homodimer while HSP90beta exists mainly as a monomer.(2) From a functional perspective, hsp90 participates in the folding, assembly, maturation, and stabilization of specific proteins as an integral component of a chaperone complex. (3-6) Furthermore, Hsp90 is highly conserved between species; having 60% and 78% amino acid similarity betwe |
| Immunogen | n/a |
| Other Names | [Hsp86; Hsp89A; Hsp90AA1; Hsp90Alpha; HspC1; HSPCA; HspCAL3], [HSP90AA1; HSP90AA1; EL52; HSPN; LAP2; HSP86; HSPC1; HSPCA; Hsp89; Hsp90; LAP-2; HSP89A; HSP90A; HSP90N; HSPCAL1; HSPCAL4; HSP90A; HSPC1; HSPCA; HSP 86; HSP86; LAP-2; LPS-associated protein 2] |
| Gene, Accession # | Gene ID: 3320, NCBI: NP_001017963.2, UniProt: P07900 |
| Catalog # | MBS800009 |
| Price | $495 |
| Order / More Info | Hsp90 alpha Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Nemoto, T. et al. (1997) J.Biol Chem. 272, 26179-26187. 2. Minami, Y, et al. (1991), J.Biol Chem. 266, 10099-10103. 3. Arlander SJH, et al. (2003) J Biol Chem 278, 52572-52577. 4. Pearl H, et al. (2001) Adv Protein Chem 59,157-186. 5. Neckers L, et al. (2002) Trends Mol Med 8:S55-S61. 6. Pratt W, Toft D. (2003) Exp Biol Med 228:111-133. 7. Pratt W, Toft D. (1997) Endocr Rev 18,306-360. 8. Pratt WB. (1998) Proc Soc Exptl Biol Med 217, 420-434. 9. Whitesell L, et al. (1994) Proc Natl Acad Sci USA 91, 8324-8328. 10. Nemoto, T. (1997) Biochem and Mol. Bio Intl. 42 (5), 881-889.1. Orthwein, A. et al. (2010). Regulation of activation-induced deaminase stability and antibody gene diversification by Hsp90. JEM. 207 (12). 2751-2765. doi: 10.1084/jem.20101321 2. Di Noia, J.M. and Orthwein, A. (2011). Modulating and/or detecting activation induced deaminase and methods of use thereof. United States Patent Application. US 20110237560 A13. O'Neill, A.J. et al. (2011). Characterisation and manipulation of docetaxel resistant prostate cancer cell lines. Mol Cancer. 10 (126). doi:10.1186/1476-4598-10-1264. Quanz, M. et al. (2012). Heat Shock Protein 90α (Hsp90α) Is Phosphorylated in Response to DNA Damage and Accumulates in Repair Foci. J Biol Chem. 287, 8803-8815. doi:10.1074/jbc.M111.320887 |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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http://www.MyBioSource.com
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